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Heparin Sodium

Name:Heparin Sodium

Heparin sodium is a white or off-white color powder, odorless, hygroscopir, freely soluble in water and insoluble in organic solvent such as ethanol, acetone, dioxane and so on .Optical rotation and characteristic absorption peak at 185-220mm,infrared characteristic absorption peak ta 890cm-1,940cm-1,absorption value at 1210-1150cm-1 was used to determine rapidly.
Heparin, a natural anticoagulant, is a kind of sulphated glycosaminoglycans. The molecule is a chain structure consisting repeated hexose or octose units, its main disaccharide units is trithionicacid disaccharide. Heparin presence in various mammalian tissues including liver lung, heart, spleen, kidney, thymus, intestinal mucosa, muscle and blood. Thus heparin can be extracted from healthy porcine intestinal mucosa and lung or healthy bovine lung, all stages of production and procurement must be conducted under the supervision of Quality Management System. The production technology is validated by the virus inactivated production process, so the harmful contaminants can be removed.

It is composed of polymers of altemating derivatives of α-D-glucosamine(N-sulfated, O-sulfated, or N-acetylated) and uronicacid (α-L- induronic acid or β-D-glucuronic acid) joined by glycosidic linkages. Some of these components have the property of prolonging the clotting time of blood.

Heparin in animal tissues bound with proteins resulted in glucoprotein complex which is a in vivo present form. So the preparation process including two steps glucoprotein extracting and dissociation, heparin isolation and purfifcation. There are sulfonic acid and carboxyl group in heparin and show highly acidic, chemical reaction between this polyanion with cation resulted in salt. The cation includs metallic cation such as Ca2+/Na+/K+, organic base pyridinium compound such as hexadecylpyridinium chloride (CPC),brucine/basicdye-azure A, cationic surface active agent (hexadecyl trimethylammonium bromide)such as cation exchanger and electropositive protein such as protamine ect.N-sulfonic acid in heparin structure is closely related with its anticoagulant actively, thus the activity will decreased after this chemical structure was destroyed. The structure is sensitive to acid hydrolysis and stable under basic condition. The dissociated hydroxyl of heparin is easy to be esterized,sulfonation will lead to activity decreasing while acetylation has no such effects.

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