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HEBEI LEAD BIO-CHEMICALS CO., LTD.
ADDRESS: No. 481, Heping West Road, Shijiazhuang 050071China
Tel No. 86-311-87826503
Fax No. 86-311-87065532
E-mail: hebeilead@gmail.com
    leadbiochem@aliyun.com 
website: www.ldbiochem.com
Products
Pharmaceutical Grade Sodium Hyaluronate
Sodium Hyaluronate is an important component of intercellular substance, eye vitreous body, joint fluid and other connective tissue. It acts the important physiologic roles in holding body's moisture, maintaining extracellular space, adjusting osmotic pressure, lubricating and promoting cells to repair in the body. Sodium Hyaluronate can be used as viscoelastic agent inintraocular lens implantation operation, as the filler in the osteoarthritis and rheumatoid arthritis and otherjoint surgery, as a medium widely used in eye drops, it also can be used to prevent postoperative adhesion and facilitate the wound heal. The compounds formed by the reaction of Sodium Hyaluronate with other drugs play a drug release effect role, thus achieve the purpose of drug targeted and time controlled release.
With the development of medical technology, Sodium Hyaluronate has been more and more widely used in medical applications.In 1976, Sodium Hyaluronate was first commercialized and used as ophthalmic viscoelastic agents, which is a significant progress in the ophthalmic industry. In 1987, Sodium Hyaluronate for intra-articular injection came in to the market. In 1990s, the large-scale production of Sodium Hyaluronate by fermentation made the cost lower, thus products containing Sodium Hyaluronate such as eye-drops, dermal fillers and other Sodium Hyaluronate preparations started to be used extensively.

Item

Standard

Appearance

White powder

Solubility

Soluble in water, practically insoluble in acetone and in anhydrous ethanol.

Glucuronic Acid

Min.46%

Sodium Hyaluronate

Min.95%

Appearance of Solution

A600nm≤ 0.01

Nucleic Acid

A260nm≤ 0.5

pH

6.0-7.5

Molecular Weight

2.0-3.0 Million Daltons

Protein 

Max.0.05%

Loss on drying

Max.10%

Residue on Ignition

Max.20%

Chlorides

Max.0.5%

Iron

Max.80ppm

Heavy metal

Max.20ppm

Arsenic

Max.2ppm

Nitrogen

3.0-4.0%

Bacteria Count

Max.10CFU/g

Molds & Yeast

Max.10CFU/g

Staphylococcus aureus

Negative

Pseudomonas aeruginosa

Negative

Hemolysis

Negative

Viable Hemolytical Streptococci

Negative

Endotoxin Level

Max.0.5 IU/ mg or Max.0.05IU/ mg


Standard: BP/EP/USP.
Molecular Weight (Dalton):
1. Medium MW: >2.0 * 106 Dalton
2. High MW: > 3.0 *  106 Dalton
Usage Scope: Cataract Surgery. Glaucoma Surgery. Corneal transplant surgery. Retinal attachment surgery. Skin filler. Anti-wrinkle. Arthritis-Injection
Package: 100g/sterile bottle. 1kg/box.
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